To address the role of mitochondria as a functional link between both T2DM and AD, mitochondrial functions were assessed in 3xTg-AD mice that present with a combined Aβ and tau pathology, wild-type mice fed with 20% sucrose-sweetened water for 7 months (T2D mice), and wild-type mice that received plain water. The gene discussed is MAPT; the disease is Alzheimer disease.