IAPP and neuroblastoma: To determine whether the same proteins or protein categories are deregulated by Aβ 42 and human amylin, we performed iTRAQ labeling followed by quantitative mass spectrometry of human SH-SY5Y neuroblastoma cells that had been treated for 5 days with aged preparations of Aβ 42, human amylin, rat amylin and the respective vehicle controls (Lim et al., 2010).