The aims of the study were to determine the expression of the NR1/NR2A/NR2B subunits and activities of nNOS/eNOS/iNOS isoforms separately in the R and L cortex of young and old Nogo-A-deficient rats, as well as to validate the animal model of schizophrenia by evaluating alterations in brain laterality. This evidence concerns the gene RTN4 and schizophrenia.