We believe that the simple age-dependent progression of changes in the pathways related to synaptic functions or apoptosis should be a characteristic sign of neurodegenerative Alzheimer disease, which incidentally is associated with Nogo-A overexpression in senile plaques (Gil et al., 2006), but not of neurodevelopmental schizophrenia. The gene discussed is RTN4; the disease is schizophrenia.