RTN4 and schizophrenia: Postmortem or genetic studies report an involvement of Nogo-A (Coon et al., 1998; Shaw et al., 1998; Novak et al., 2002; Tan et al., 2005; Novak and Tallerico, 2006; Jitoku et al., 2011) or its receptor (Sinibaldi et al., 2004; Hsu et al., 2007; Budel et al., 2008) in schizophrenia; however, changes such as varying Nogo-A mRNA levels in the autoptic frontal cortices of psychotic patients are not marked, in contrast to those in Nogo-C mRNA (Novak and Tallerico, 2006).