Nevertheless, young adult Nogo-A knock-out rodents show schizophrenia-like abnormalities in behavioral tests (e.g., deficient sensorimotor gating, disrupted latent inhibition, perseverative behavior, and increased sensitivity to the locomotor stimulating effects of amphetamine) and in neurochemical analysis (e.g., altered monoaminergic transmitter levels and changes in dopamine D2 receptor levels in striatal and limbic regions) (see Willi et al., 2010; Tews et al., 2013). This evidence concerns the gene RTN4 and schizophrenia.