GNRH1 and diabetes mellitus: Based on the above mentioned findings and considering that (1) in the nonobese mouse model of autoimmune diabetes (NOD mouse), castration of male NOD mice leads to increased incidence of diabetes, and that (2) castration of male mice leads to an increase in GnRH action, Ansari et al. (2004) determined the effect of GnRH agonists and antagonists on expression of autoimmune diabetes in this mouse model.