A recent study demonstrating two different modes of glutamate release in astrocytes provides a new way of thinking for epilepsy: TREK-1, a two-pore potassium channel, can be responsible for fast glutamate release induced by GPCR (G-protein coupled receptors) activation and Bestrophin-1 (Best1), a calcium activated anion channel for slow release (Woo et al., 2012). Here, BEST1 is linked to epilepsy.