NFE2L2 and cancer: Experimental studies with cell and animal models have provided evidence that isothiocyanates, derived from glucosinolates that specifically accumulate in these vegetables, may mediate a reduction in cancer and CVD risk through a multitude of mechanisms, the most prominent of which is induction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)–antioxidant response element–mediated phase II detoxification and antioxidant gene expression (17–20).