PPARGC1A and atherosclerosis: It is likely that CLA mediated regulation of both PGC-1α and RORα may regulate Cyb7b1 since it has previously been shown that in RORα−/− mice, which develop severe atherosclerosis, there is suppression of Cyp7b1 expression suggesting RORα may be a positive regulator of Cyp7b1 (Wada et al, 2008).