CRP and hypertensive disorder: The elevation in CRP observed in the study by Trotti et al., the activation of the HIF pathway reported in the autopsy study by Patton et al., and the results of the studies in patients with gastrointestinal diseases (GI) by Weinstock et al., all propose cellular mechanisms that have been identified to contribute to hypertension, CVD, and stroke and may also be related to the expression of RLS/PLMS [90, 120, 128–131].