MAPT and tauopathy: Given that tau species phosphorylated on KXGS motifs accumulate in NFTs (19), fail to bind and stabilize microtubules (15) and are also primed for phosphorylation by other kinases (20,21), our results show that augmenting acetylation of KXGS motifs on tau is a promising approach to slow or prevent disease progression in tauopathies.