The IGF system is a complex network of growth factors (IGF-I and IGF-II), cell surface trans-membrane receptors (IGF1R), and high affinity IGF-binding proteins (IGFBPs) that play an important role in normal cellular growth and development, and disruption of the balance of this system has been implicated in the etiology and progression of breast and other cancers[15]. Here, IGF1R is linked to cancer.