FAS and Cirrhosis: Moreover the promoter polymorphism FAS -670 T > C results in higher expression of FAS on the surface of activated T cells (Sun et al. 2005) and, although this polymorphism has not been associated with overall susceptibility to type 1 AIH, the minor allele FAS -670C was found to confer protection against early onset cirrhosis in Caucasian type 1 AIH patients (Agarwal, Czaja et al. 2007).