In order to gain insight into the mechanisms that albumin-associated lipid enriched media acts as a transdifferentiating media for human cancer cell lines (HCCLs) (Ruiz-Vela et al.[2011]; Ruiz-Vela et al.[2009]), we examined how gene expression in MALME-3M cells is regulated during the transdifferentiation process, using deep sequencing. Here, ALB is linked to cancer.