AR and cancer: It is conceivable that the FRA expressing cancers may fall into the basal-like category that are also known to sometimes be BRCA(+), characterized high grade infiltrating ductal carcinomas that can show necrosis ([Metzger-Filho et al. 2012]), or by contrast the luminal androgen receptor subtype that often present with bone and lymph node involvement but are more indolent by nature ([Gelmon et al. 2012]).