ESR1 and metastatic neoplasm: In metastatic disease, there was a significant difference between FRA(+) samples that were also ER/PR(+) or ER/PR(−) (p = 0.0054), as seen on the TMA, but also a significant difference in FRA expression by grade of disease (grade 1 or grade 2 versus grade 3, p = 0.037).