FOLR1 and neoplasm: Two primary approaches have been explored, one involving targeted drug delivery via folate-conjugated therapeutic compounds that binds both FRA and FRB ([Low & Kularatne 2009]; [Dosio et al. 2010]), while another approach involves direct targeting and tumor cell death via humanized anti-FRA monoclonal antibodies ([Ebel et al. 2007]; [Konner et al. 2010]; [Spannuth et al. 2010]).