BRCA1 and ovarian carcinoma: The identification of the two major hereditary breast/ovarian cancer genes, BRCA1 (17q21, MIM* 113705) in 1994 [3] and BRCA2 (13q14, MIM* 600185) in 1995 [4], led to a new era in the diagnosis of inherited high predisposition to breast and ovarian cancer [5, 6].