While ADA guidelines do not have a specific target recommendation for geriatric patients and contemplate individualization of hemoglobin (Hb) A1c (HbA1c) goals for many non-pregnant adults with diabetes [2], American Geriatric Society (AGS) guidelines suggest a target of 8.0 % in frail geriatric patients with diabetes [3]. This evidence concerns the gene GSTM1 and diabetes mellitus.