In a study of hypertensive patients by Okura et al. [53], in a stepwise regression analysis model using baseline RRI, age, PP, glycosylated hemoglobin, C-reactive protein, cystatin C and urinary albumin/creatinine ratio, only the baseline RRI was a marker of renal dysfunction in a 1-year observation. This evidence concerns the gene CRP and Abnormal renal physiology.