It is believed that IFN-α, induced by IFI27 [27], stimulates myeloid dendritic cells to activate IL-12, which in turn prompts T-cells to secrete IFN-γ, and arms NK cells and CD8+ cytotoxic T lymphocytes (CTL) with perforin A and granzyme B for killing tumor targets [28]. Here, GZMB is linked to neoplasm.