Since the ACE protein level is also increased in the brains of patients with Alzheimer’s disease, and all components of the angiotensin-AT1 receptor system are present in different regions of the human brain [27,28,43], future studies will have to determine whether the neuro-regenerative potential of captopril documented in AD mice could be also of relevance for individuals at risk of developing cognitive impairment or AD. Here, ACE is linked to early-onset autosomal dominant Alzheimer disease.