If take the nuclear maspin expression level of tumor emboli in metastatic lymph nodes as the “baseline” and draw the curve of nuclear maspin expression from normal cervix to metastatic carcinoma, it will show a peak in CIN3 and then gradually dropped which indicate that nuclear maspin first react to oncogenic factors and then direct the change of maspin in cytoplasm. Here, SERPINB5 is linked to metastatic carcinoma.