After Zou et al. [4] first reported that maspin expression obviously descended in invasive breast carcinoma, the same expression pattern had been discovered in many other kinds of tumors such as prostate cancer, renal cell carcinoma, oral cavity squamous cancer, gastric carcinoma and colonic cancer [3, 5, 7, 27]. The gene discussed is SERPINB5; the disease is hereditary clear cell renal cell carcinoma.