The upregulation of NUCB2 mRNA in PCa tissues was correlated with the higher Gleason score (P < 0.001), the higher level of preoperative PSA (P = 0.004), the positive lymph node metastasis (P = 0.022), and the positive angiolymphatic invasion (P = 0.004). Here, KLK3 is linked to posterior cortical atrophy.