APOE*4 has been shown to augment injury and worsen outcome in various models of neurodegeneration, including cerebral hemorrhage [20], traumatic brain injury (TBI) [21], stroke [8,11,22] and global brain ischemia [23], and has been suggested to be a significant risk factor for cognitive impairment in the early phase after stroke [24]. This evidence concerns the gene APOE and Cognitive impairment.