Monitoring the weight of the mice revealed 20% greater body weight in ApoE3-TR mice (38.1 ± 6.0 g) compared with WT (30.5 ± 3.1 g) and ApoE4-TR (31.4 ± 3.4 g) mice prior to the diet (P < 0.001) and the difference lasted throughout the HF diet period. Here, APOE is linked to hydrops fetalis.