APOE and hydrops fetalis: We assessed the contribution of ApoE4 to the outcome of focal brain ischemia in aged mice maintained on a HF diet and show for the first time that ApoE4 together with long-term intake of a HF diet containing 5.3 times more fat and having 1.5 times higher energy density compared with normal chow leads to significant sensorimotor deficits as analyzed by an adhesive removal test.