Our results show that pharmacological AC5 inhibition protects against tumor growth and against both tumor cell and host mechanisms facilitating tumor growth (proliferation, adhesion, migration, angiogenesis) in syngeneic mouse models and in murine tumor cell lines; for example, LP07 lung adenocarcinoma (Urtreger et al., 2001; Peluffo et al., 2004), LLC1, B16F10 melanoma cells (Fig. S2). This evidence concerns the gene ADCY5 and melanoma.