HPN and posterior cortical atrophy: There are many emerging markers that show promise for PCa diagnosis, such as alpha-methylacyl-CoA racemase (AMACR) [13], prostate cancer gene 3 (PCA3) [14], early prostate cancer antigen (EPCA)-2 [15], Hepsin [16], kallikrein-related peptidase 2 (KLK2) [17], and polycomb group protein enhancer of zeste homolog 2 (EZH2) [18].