The patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C>G single nucleotide polymorphism is a genetic determinant of liver fat accumulation [69] able to influence fibrosis severity in NAFLD patients [70], and it has been associated with severe steatosis, fibrosis stage, treatment response, and HCC occurrence in subjects with CHC [71]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.