In this regard, our group reported a remarkable increase of homocysteine serum levels in genotype 1 CHC patients, not related to MTHFR status, and an independent association between MTHFR C677T homozygosis and higher total and LDL-cholesterol levels, a link which could suggest a possible indirect interference of MTHFR status, via modulation of cholesterol levels, on liver fibrosis and response to antiviral therapy [151]. The gene discussed is MTHFR; the disease is Hepatic fibrosis.