DHCR7 and cryohydrocytosis: In addition, on the basis of a recent genome-wide study which identified genetic variants affecting 25(OH)D serum levels in healthy populations [109], our group recently reported that GG homozygosis for rs12785878 DHCR7 gene (one of the polymorphism linked to lower serum levels of [25(OH)D], near dehydrocholesterol reductase), together with lower 25(OH)D levels, is independently associated with the severity of liver fibrosis in patients with genotype 1 CHC, thus suggesting that DHCR7 genotype could also prompt fibrogenesis by itself via other direct/indirect mechanisms [110].