In the current study, by using morpholino-[124I]IPQA with PET, we demonstrated that L858R and E746-A750 del EGFR mutated cells, which are the most frequent mutation in NSCLC [9], showed significant increased accumulation of radiotracer when compared to the wild-type EGFR-transfected and vector-transfected cells in vitro and in vivo. This evidence concerns the gene EGFR and non-small cell lung carcinoma.