These observations were partially confirmed by Du et al. using an immunohistochemical study; they added that Mena intensity does not depend on the histological type of HER-2-positive breast carcinomas and can also be observed in about 7% of normal breast tissue [23], although Di Modugno et al. denied detection of hMena isoforms in normal breast tissue [5, 8]. This evidence concerns the gene ERBB2 and breast carcinoma.