It was first identified in mouse, when other splicing-derived isoforms of pan-Mena were described: a human homologue (pan-hMena), a variant present in primary tumor cells but lost in invasive cells (Mena11a), two invasive forms (MenaINV or Mena++ and Mena+++), and the subtype MenaΔv6 [1, 2, 4–8]. The gene discussed is ENAH; the disease is neoplasm.