The isoform 11a is expressed in both premalignant and malignant cells, and, during tumor progression, it seems to be downregulated; at the same time, a tumor-environment-dependent switching pattern occurs, and the pan-Mena isoforms ++ and +++ become upregulated when tumor cells become invasive in vivo, in both human and mice [6]. Here, EGFR is linked to neoplasm.