Considering that TH modulate a number of physiological functions in CNS, including development, function, expression of adenosine A1 receptors, and transport of neuromodulator adenosine, we investigated the effects of the hyperthyroidism and hypothyroidism on the hydrolysis of the ATP to adenosine in the synaptosomes of hippocampus and cerebral cortex of rats in different developmental phases [55, 56]. Here, ADORA1 is linked to hyperthyroidism.