Dai et al. found that Herba Scutellariae Darbatae Radix (HSDR) effectively inhibits the proliferation and induces apoptosis of H22 cells involving loss of mitochondrial transmembrane potential, release of cytochrome C, and activation of caspase-3 in a dose-dependent manner [29].The effect of HSDR on immune function was determined using hepatoma H22 tumor bearing mice. Here, CASP3 is linked to hepatocellular carcinoma.