However, these findings should be considered with caution, due to the rather low number of CVID patients carrying TNFRSF13B/TACI defects, as well as to the fact that the true prevalence of granulomas formation in CVID is rather underestimated, since not all patients with lymphoproliferation and/or hepatic or lung infiltrates are subjected to biopsy. This evidence concerns the gene TNFRSF13B and common variable immunodeficiency.