ATXN2L and trigeminal nerve disorder: There is a good agreement between guidelines (such as those of the International Association for the Study of Pain Neuropathic Pain Special Interest Group) that tricyclic antidepressants, alpha-2-delta ligands (α2-δ ligands) (gabapentin and pregabalin), serotonin-norepinephrine reuptake inhibitors (venlafaxine and duloxetine), carbamazepine (for trigeminal neuralgia), and topical lignocaine (for localised peripheral neuropathic pain) are the first-line drugs; tramadol and opioids are second-line drugs [32].