Comer et al. [16] showed that cigarette smoke extract (CSE) pretreatment of primary bronchial epithelial cells (PBECs) followed by P. aeruginosa LPS stimulation reduced IL-8 release from COPD PBECs but increased it from cells of smokers without airflow obstruction and nonsmokers. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.