Finally, we examined a mouse model of MCDS resulting from a mutation in the NC1 domain of type X collagen (Col10a1 N617 K), and demonstrated that the relative levels of both Armet and Creld2 were increased within the chondrocytes and ECM of the hypertrophic zone (Fig. 2C). Here, CRELD2 is linked to Schmid metaphyseal chondrodysplasia.