Mice that ectopically express Δ40p53, a p53 mutant that lacks part of the transactivation domain, also exhibit glucose intolerance, hypoinsulinemia, and defects in β cell mass and proliferation, suggesting that p53 plays a role in the regulation of β cell proliferation (Hinault et al., 2011). The gene discussed is TP53; the disease is Glucose intolerance.