Indeed, adipocytes from obese mice display elevated levels of p53 (Yahagi et al., 2003), and liver p53 levels are induced in mouse models of hepatic steatosis (fatty liver disease) associated with obesity (Yahagi et al., 2004) and chronic alcohol consumption (Derdak et al., 2011). This evidence concerns the gene TP53 and obesity due to melanocortin 4 receptor deficiency.