BRAF and melanoma: Although it might be questioned whether patients with stage IIB melanoma should also be included in the adjuvant therapy clinical trials, despite the promising leads mentioned above there is currently not a lot of prognostic information that supports the use of mutant BRAF targeted therapy to treat stage III melanomas in the adjuvant setting, and even less information to support the use of BRAF targeted therapy to treat stage IIB-C melanomas.