The region located between 3p21.3 and 3p14.3, deleted in both cell sub-lines, contains several established tumor suppressor genes including LTF, TDGF1, WNT5a, and RASSF (37), as well as candidate tumor suppressors such as CACNA2D3, GNAI2, and SEMA3B. The gene discussed is CACNA2D3; the disease is neoplasm.