To conclude, we have completed a proteomic analysis of Matn3 V194D, Comp T585M and Comp DelD469 models of chondrodysplasia and demonstrated that the mutation of matrilin-3 or COMP can induce changes to the extractability of other cartilage proteins confirming that there are disruptions to the organization of the cartilage ECM. Here, MATN3 is linked to chondrodysplasia.