Otherwise, key genes have been emerged through our analysis related to the formation of the atherosclerosis plaque affected in DS, i.e. upregulation of ANXA2 (Seidah et al., 2012), although other factors like sex hormones (El Khoudary et al., 2012; Mendelsohn and Karas, 2005; Suzuki et al., 2010) can also be related to this feature. This evidence concerns the gene ANXA2 and atherosclerosis.