Of special interest are the ones that can be associated to DS pathogenesis; among them we have found genes related to heart organogenesis (i.e. VCAN, which is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development (Hatano et al., 2012)), related to atherosclerosis or coronary artery diseases (i.e. ANXA2) (Seidah et al., 2012). Here, ANXA2 is linked to atherosclerosis.