In this study, melioidosis with meningitis exhibited the following characteristics: (1) Severe bacteremia was not necessary; (2) neutrophil infiltration into the meninges and bacterial burdens in the brain occurred during the second (phase III) but not the first (phase I) decline phase; (3) meningitis was induced by infected CD11b+ cells but not by extracellular (free) bacteria; and (4) selectin was involved in the onset of meningitis. This evidence concerns the gene ITGAM and infectious meningitis.