In particular, folate and hcy values, as well as MTHFR 677CC, MTHFR 677TT, MTHFR 1298CC, TYMS 28bp 2R/3R, TYMS 1494 6bp +/+, TYMS 1494 6bp +/-, MTRR 66AG, MTR 2756GG, RFC1 80GA, DNMT3B-149CT, DNMT3B-149TT, DNMT3B-579GG, DNMT3B-579GT, and DNMT3B-579TT genotypes resulted the most important variables for discriminating between AD and control subjects (Table 3). This evidence concerns the gene RFC1 and Alzheimer disease.