Finally, and most importantly, the involvement of PRSS1 contributed directly to the identification of two further chronic pancreatitis susceptibility genes, SPINK1 (encoding pancreatic secretory trypsin inhibitor; MIM #167790) [13] and CTRC (encoding chymotrypsin C, a trypsin-degrading enzyme [14]; MIM #601405) [15,16]. Here, CTRC is linked to chronic pancreatitis.