MAPK3 and neoplasm: The inhibition of oncogenic EGFR signaling such that the phosphorylation level of EGFR, AKT, and ERK1/2 is markedly reduced by specific silencing of oncogenic EGFR, may trigger cell death involving a caspase activation [23,24] (Figures 2E, 3D and Figure S4), thereby suppressing tumor cell growth.