To investigate how post-translational modifications, such as phosphorylations, could impact on the binding affinity of rHuR we stimulated transfected cells for 3 hr with cyclosporine (CsA) [4 μM], a compound able to induce in 786-0 renal cancer cells the HuR nucleo-cytoplasmic shuttling, its association with PKC-δ and its phosphorylation [23]. The gene discussed is ELAVL1; the disease is renal carcinoma.