However, this SNP has the capacity to change the TGFBR2 mRNA expression levels in PC patients submitted to ADT and influence the CRFI, with a lower time interval to CR in TGFBR2-875GG homozygous compared with TGFBR2-875AG/AA patients carriers. The gene discussed is TGFBR2; the disease is pachyonychia congenita.