Furthermore, multivariate Cox regression model using tumor stage, Gleason≥ 8, and PSA levels at diagnosis as covariants, demonstrated a higher risk of earlier relapse in TGFBR2-875GG PC patients following ADT (hazard ratio- HR= 1.47, 95%CI: 1.05-2.05, P= 0.024) (Figure 1). The gene discussed is TGFBR2; the disease is pachyonychia congenita.