The inactivation of TGFBR2 gene in mouse fibroblasts has been associated with prostate intraepithelial neoplasia and invasive squamous cell carcinoma of forestomach development, and this alteration can also promote growth and invasion of co-transplanted breast cancer cells [20,21]. The gene discussed is TGFBR2; the disease is prostate intraepithelial neoplasia.