CD8A and infection: However, at 4 d post-infection, when YK511 (Us3K220M) had induced more HSV-1-specific CTLs than YK513 (Us3-repair), as described above (Fig. 6), depletion of CD8+ T cells significantly (6-fold) increased replication of YK511 (Us3K220M) in the footpads, but had no effect on replication of YK513 (Us3-repair) (Fig. 7A).