IQGAP2 and hepatocellular carcinoma: Analysis of a subset of 371 genes that were differentially expressed with age (i.e. between 6-month-old and 24-month-old groups) in KO but not in WT livers confirmed that the Wnt/β-catenin signaling pathway is the top canonical pathway altered in HCC tumors in the Iqgap2−/− mouse model (Table 1 A).