Among these, a short list of potential cancer molecular drivers highly relevant for HCC, whose expression was most significantly altered in Iqgap2−/− livers in age-dependent manner, included Afp, Nlk, Sp5, and Wif1 (up-regulated expression); and Igfbp3, Igfbp5, and Cadherin1 (down-regulated expression). Here, SP5 is linked to hepatocellular carcinoma.