AQP1 and leptospirosis: Leptospirosis exhibits well-known alterations of the endothelium in different tissues and organs, and it is attractive to suggest that the changed endothelial expression of CD34, and possibly aquaporin 1, as seen both by conventional and confocal microscopy, are part of a primary non-inflammatory injury to the microcirculation of the lung in leptospirosis.