On the basis of analysis of 203 case patients and 411 gender-matched normal controls, in accordance with the previous studies on esophageal squamous cell carcinoma and lung cancer [26], [28], it was demonstrated that subjects carrying the FAS -1377AA or GA genotype presented an increased risk for developing NB compared with the non-carriers. The gene discussed is FAS; the disease is esophageal squamous cell carcinoma.