Additionally, after experimental spinal cord injury, the development of central neuropathic pain was associated with the upregulation of several proinflammatory cytokines [72] as well as other proteins such as S100ß, glial fibrilary acidic protein (GFAP), and AQP-4 [73], the latter representing the target antigen in NMO [7]. This evidence concerns the gene GFAP and neuromyelitis optica.