In present study, we aimed to clarify the contribution of HLA-DRB1, DQA1and DQB1 alleles and DR-DQ haplotypes to RA susceptibility in Han population, and to further determine whether certain DR-DQ haplotypes were specifically associated with RA subsets, e.g. anti-CCP positive/nagetive RA. This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.