Braak and Braak [5] found that tau (neurofibrillary tangle and neuropil thread) deposition in the hippocampus first occurs on the medial and lateral side of the CA1 field in the early phase of AD (stage II, their Fig. 4); these regions are also more affected in the later phases than the middle portion of the CA (superior portion of the 3D hippocampus, see Methods) or the subiculum (infero-medial portion of the 3D hippocampus). Here, MAPT is linked to Alzheimer disease.