NUP98 and infection: Taken together with previous reports from our and other groups, our data lead us to propose a model of HRV16 infection (Figure 4) whereby 2A protease mediates the initial cleavage of Nup98 early during infection (starting at 3 h p.i.), with cleavage of Nup153 by 3C protease following at about 6–9 h p.i., at which time 3C is localised to the nucleus.